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Thomas Brenn , M.D., Ph.D.

Dr. Brenn received his M.D. and Ph.D. with magna cum laude from Ruprecht-Karls University of Heidelberg, Gremany. He trained in pathology at the Brigham and Women's Hospital and Harvard Medical School in Boston, MA. His training included extensive experience in soft tissue pathology under the direction of Prof. Christopher M.D. Fletcher. He then completed the Harvard Combined Dermatopathology fellowship training at the Harvard-affiliated hospitals, Brigham and Women's Hospital under the direction of Prof. P.H. McKee, Massachusetts General Hospital under Dr. Martin C. Mihm, and Beth Israel Deaconess Hospital under Dr. Steven Tahan.

He served as a Staff Dermatopathologist at the Brigham and Women's Hospital and Assistant Professor of Pathology at Harvard Medical School. In 2006, he moved to the U.K. where he is currently a Consultant Dermatopathologist at NHS Lothian University Hospitals Trust in Edinburgh.

Dr. Brenn's clinical and research interests are focused on dermatopathology and soft tissue pathology. He is a sought after speaker at the national and international Continued Medical Education Courses and contributor to medical texbooks.

Dr. Brenn holds medical licenses in Europe and the United States of America (U.K.)

Selected publications:

Authored Book Chapters:

1. Brenn T and McKee PH. 2005

  • Tumors of surface epithelium.
  • Tumors of the hair follicle.
  • Tumors of the sweat glands.

In: “Pathology of the Skin”, McKee PH, Calonje JE, Granter S (eds.), chapters 22, 27, 29. Mosby.

2. Brenn T, McKee PH and Mihm MC. 2005

  • Vascular neoplasms.

In: “Cancer of the skin”, Rigel DS, Friedman R, Dzubow LM, Reintgen DS, Bystryn J-C, and Marks R (eds.), chapter 26. W.B. Saunders.

3. Brenn T. 2005

  • Cutaneous Myoepithelioma.
  • Microcystic Adnexal Carcinoma.

In: “Cases in Dermatopathology. Adnexal Neoplasms”, Zembowicz A, Flotte T, Mihm MC, Murphy GF, Tahan S (eds.), chapters 14 and 15. KBS Publishing.

4. Brenn T. 2006

  • Cutaneous Myoepithlioma.

In: “Cases in Dermatopathology. Common Problems in Diagnosis of Pigmented Lesions”, Zembowicz A, Flotte T, Mihm MC, Murphy GF, Tahan S (eds.), chapter 29. KBS Publishing.

5. Brenn T. 2007

  • Neoplasms of Subcutaneous Fat.

In: “Fitzpatrick’s Dermatology in General Medicine”, Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller A, Leffell DJ (eds.), chapter 129. McGraw-Hill.


Original Peer-reviewed Articles

1. Haass M, Richardt G, Brenn T, Schömig E, Schömig A. Nicotine-induced release of noradrenaline and neuropeptide Y in guinea-pig heart: role of calcium channels and protein kinase C. Naunyn-Schmiedebergs Arch Pharmacol 1991, 344(5):527-31.
2. Richardt G, Brenn T, Seyfarth M, Haass M, Schömig E, Schömig A. Dual effect of nicotine on cardiac noradrenaline release during metabolic blockade. Basic Res Cardiol 1994, 89(6):524-34.
3. Eldadah ZA, Brenn T, Furthmayr H, Dietz HC. Expression of a mutant human fibrillin allele upon a normal human or murine genetic background recapitulates a Marfan cellular phenotype. J Clin Invest 1995, 95(2):874-80.
4. Francke U, Berg MA, Tynan K, Brenn T, Liu W, Aoyama T, Gasner C, Miller DC, Furthmayr H. A Gly1127Ser mutation in an EGF-like domain of the fibrillin-1 gene is a risk factor for ascending aortic aneurysm and dissection. Am J Hum Genet 1995, 56(6):1287-96.
5. Schmidt MC, Klues HG, vom Dahl J, Brenn T, Hugel W, Hanrath P. Intracoronary Doppler flow velocity measurements in two patients with solitary coronary ostium: is there true obstruction? Coron Artery Dis 1996, 7(10):761-5.
6. Liu W, Qian C, Comeau K, Brenn T, Furthmayr H, Francke U. Mutant fibrillin-1 monomers lacking EGF-like domains disrupt microfibril assembly and cause severe Marfan syndrome. Hum Mol Genet 1996, 5(10):1581-7.
7. Brenn T, Aoyama T, Francke U, Furthmayr H. Dermal fibroblast culture as a model system for studies of fibrillin assembly and pathogenetic mechanisms: defects in distinct groups of individuals with Marfan's syndrome. Lab Invest 1996, 75(3):389-402.
8. Schrijver I, Liu W, Brenn T, Furthmayr H, Francke U. Cysteine substitutions in epidermal growth factor-like domains of fibrillin-1: Distinct effects on biochemical and clinical phenotypes. Am J Hum Genet 1999, 65 (4): 1007-1020.
9. Liu W, Schrijver I, Brenn T, Furthmayr H, Francke U. Multi-exon deletions of the FBN1 gene in Marfan syndrome. BMC Med Genet 2001, 2 (1): 11.
10. Schrijver I, Liu W, Odom R, Brenn T, Oefner P, Furthmayr H, Francke U. Premature termination mutations in FBN1: distinct effects on differential allelic expression and on protein and clinical phenotypes. Am J Hum Genet 2002, 71(2): 223-37.
11. Brenn T, Calonje E, Granter SR, Leonard N, Grayson W, Fletcher CD, McKee PH. Cutaneous Rosai-Dorfman disease is a distinct clinical entity. Am J Dermatopathol 2002, 24(5): 385-91.
12. Brenn T and Fletcher CD. Cutaneous epithelioid angiomatous nodule: a distinct lesion in the morphologic spectrum of epithelioid vascular tumors. Am J Dermatopathol 2004, 26(1): 14-21.
13. Brenn T and Fletcher CD. Radiation-induced cutaneous atypical vascular lesions and angiosarcoma: Clinicopathologic analysis of 42 cases. Am J Surg Pathol 2005, 29(8): 983-996.
14. Natarajan E, Omobono JD 2nd, Guo Z, Hopkinson S, Lazar AJ, Brenn T, Jones JC, Rheinwald JG. A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence. Am J Pathol 2006, 168(6): 1821-37.
15. Tolland JP, Brenn T, Guldbakke KK, Schanbacher CF. Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma. Dermatol Surg. 2006 Oct;32(10):1294-301.
16. Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zemboxicz A, Mihm MC, McKee PH, Brenn T. Atypical genital nevi: a clinicopathologic analysis of 56 cases. Am J Surg Pathol 2008, 32(1): 51-57.
17. Hollmann TJ, Brenn T, Hornick JL. CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis. Am J Surg Pathol 2008, 32(1): 139-145.

Review Articles

1. Richardt G, Haass M, Brenn T, Schömig E, Schömig A. 1991 Nicotine-induced release of noradrenaline and neuropeptide Y in the heart: dependence on calcium, potassium and pH. In “Effect of nicotine on biological systems”, Adlkofer F, Thurau K (eds.), pp 197-203. Birkhäuser Verlag, Basel.
2. Brenn T and Fletcher CDM. Post-radiation vascular proliferations: an increasing problem. Histopathology 2006 48:106-114.
3. Brenn T and McKee PHM. Melanoma in children and adolescents. Diagnostic Histopathology 2008, 14: 18-27.